Study Characterizes Endotypes of Childhood Asthma Severity in African American Patients

The July 2017 edition of PLoS One includes an article that “sought to characterize endotypes of childhood asthma severity in African American patients in an inner-city pediatric asthma population.” In order to do this, researchers took “baseline blood neutrophils, eosinophils, and 38 serum cytokine levels” of 235 asthmatic children.  Patients were then classified as “Easy-to-Control or Difficult-to-Control based on the required dose of controller medications over on year of prospective management.” Researchers then used a “multivariate variable selection procedure” to “select cytokines associated with Difficult-to-Control versus Easy-to-Control asthma.”

The researchers found “12 cytokines were significant predictors of Difficult-to-Control asthma.” It was also shown that “in addition to blood eosinophils and neutrophils, serum cytokines improved the fit of the model.” The concluded that “these data may contribute to risk stratification of Difficult-to-Control asthma in the African American population.”

To read the article’s abstract, click here.