Role of Rhinovirus Infections in the Development of Childhood Asthma

In a study published in the April edition of the Journal of Allergy and Clinical Immunology, researchers utilizing advanced molecular diagnostics have identified rhinoviruses (HRVs) as pathogens frequently causing wheezing illnesses in infants and young children. Wheezing during HRV infection in early life identifies children at particularly high-risk of asthma development. Plausible mechanisms by which HRV could cause airway damage, promote airway remodeling, and lead to asthma development have recently been identified. This review identified mechanisms by which HRV lower respiratory tract infection, particularly in a susceptible host, could promote the development of childhood asthma. Further studies are needed to elucidate the mechanisms underlying the link between HRV wheezing in early childhood and subsequent asthma development, with the critical goal of identifying novel therapeutic and prevention strategies for both early childhood wheezing and asthma. For access to the complete article, please click here.